[Axon Medchem 한국공식대리점] VE 822

[Axon Medchem 한국공식대리점] VE 822

[VE 822]

 

Product Description:

Selective ATR inhibitor (IC50 values 0.019 µM, 2.6 µM, and 18.1 µM for ATR, ATM, and DNA-PK, respectively)로 체외 및 생체 내 활성을 지니며 방사선 조사 암세포에서 세포주기 체크포인트 유지 및 상동 재조합을 감소시키고 지속적인 DNA 손상을 증가시킵니다.
VE822는 XRT 또는 gemcitabine에 대한 반응에서 정상 세포는 아니지만 췌장암 세포의 생존율을 감소시켰습니다.

• CAS: 1232416-25-9
• Purity: 99%
• Solubility: Soluble in 0.1N HCl(aq) and DMSO
• MF: C24H25N5O3S
• MW: 463.55

References:

• E. Fokas et al. Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation. Cell Death Dis. 2012 Dec 6;3:e441.

 

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